MESOscope

A Nonlinear Optical Microscope providing millimeterscale Field-of-View with submicron digital resolution

MESOscope is a patented, industry-leading nonlinear optical microscope with up to 4 parallel channels, delivering submicron digital resolution across a millimeter-scale field of view—meeting the Nyquist-Shannon criterion. Its detachable external stage supports both ex vivo and in vivo imaging. GPU-accelerated mosaic stitching enables post-processing-free, sub-minute gigapixel scans at >500 Mbps. A proprietary high-speed mode supports multichannel kilohertz frame-rate imaging for functional studies. Compact and versatile, MESOscope fits a wide range of experimental needs.

mesoController is a powerful, high-speed imaging and scanning solution specifically designed for advanced microscopy applications. It features up to 4 parallel acquisition channels for efficient data collection, ultrafast sampling rates up to 125 MSps, and high-speed imaging at up to 800 fps.The system supports both resonant and galvanometer scanners, along with integrated high-voltage PMT power supplies for up to 4 channels. It also includes jitter-free line triggers, external trigger support, and GPU-accelerated image acquisition and processing software. Combining these features, the mesoController provides an all-in-one, customizable solution, ideal for optical microscopy applications in both research and industrial environments.

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Streamline your research with MESOscope
High resolution neuronal structures
Mouse brain medulla (tdTomato)
Intact trigeminal tract (tdTomato)

Advantages

  • Millimeter-scale field-of-view (FOV)
  • Submicron digital resolution
  • Nyquist-fulfilled ultrafast sampling
  • Kilohertz frame-rate imaging
  • Compact and adaptable design
  • Dual 3D-stage mechanism
Model MESOscope
Excitation wavelength 900–1100 nm
Operating channels 2
Fast axis frequency 4 kHz
Field of View (FOV) 0.7 mm × 0.7 mm (20x)
Max. image size 4096 × 4096
*Subject to laser repetition rate
Numerical aperture ≥ 0.8
Bidirectional scan Yes
Ultrafast sampling Yes (up to 80 M/s)
*Subject to laser repetition rate
3D stage External
(25 mm XY, 20 mm Z)
Computer Included
(2 TB SSD, 32 GB RAM, 16 GB Graphics)
Monitor Included 4K (3840 × 2160)
External controller None
Software Basic imaging (up to 2 channel)
Operating temperature 20–35 °C
Power input 125/250V AC
50/60 Hz
Model MESOscope Pro
Excitation wavelength 900–1100 nm
Operating channels 4
Fast axis frequency 4 kHz or 8 kHz
Field of View (FOV) 1 mm × 1 mm (20x, 4 kHz)
0.4 mm × 0.4 mm (40x, 8 kHz)
Resolution 1 µm digital resolution
fulfills the Nyquist–Shannon Sampling Theorem
Max. image area 10 mm × 10 mm
(mosaic-stitching, 4 kHz)”
Max. image size 8192 × 8192 (4 kHz)*
Numerical aperture ≥0.8
Bidirectional scan Yes
Ultrafast sampling Yes (up to 125 M/s)*
Bright field imaging Yes (CMOS)
3D stage External (25 mm XY, 20 mm Z)
Internal (10 mm Z)
Computer Included
(4 TB SSD, 64 GB RAM, 24 GB Graphics)
Monitor Included 4K (3840 × 2160)
External controller None
Software Basic imaging (up to 4 channels)
Denoised Contrast Enhancement (DCE)
Real-time mosaic-stitching
Operating temperature 20–35 °C
Power input 125/250V AC
50/60 Hz
Model mesoController
Operating Channels Up-to 4 parallel channels
Resonant Scanner 4 kHz or 8 kHz or 12kHz
*Supports scanners from:
Cambridge technology
Electro-Optical Products Corporation (EOPC)
Galvanometer scanner Supports scanners from: Cambridge technology Thorlabs
Jitter-free line trigger Supports phase-locked loop trigger system for jitter-suppressed line triggering
Ultrafast sampling Up-to 80 MSps or 125 MSps with up-to 4 parallel channels
High-speed imaging Up to 800 fps
Max. image size 8192 × 8192 (4 kHz)*
Bidirectional scan Yes
High voltage control for Photomultiplier tubes Up-to 4 photomultiplier tubes, each channel providing up-to –1200V
3D stage Supports linear stages from Zaber Technologies
Laser safety Supports automatic motorized shutter mechanism
External trigger Supports external triggering for acquisition control (for synchronizing with experimental setup)
Software Includes GPU-accelerated software mesoXScan for acquisition and data processing
Dimension 323mm × 282mm × 48mm (approx.)
Operating temperature 20-35 °C
Power input 125/250V AC, 50/ 60 Hz

Streamline your research with MESOscope

Streamline your research with MESOscope

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