MESOscope - mesoView Co., Ltd.

MESOscope- MS100

"A Nonlinear Optical Microscope providing millimeter-scale Field-of-View with submicron digital resolution"

MS100 is a 4-channel Nonlinear Optical Microscope delivering a millimeter-scale FOV with a submicron digital resolution while employing a high-speed resonant scanner. It supports ultrafast acquisition up to 1500 fps (4 channels, 16 Y-lines), enabling high-speed functional imaging with precise temporal fidelity. With its One-Click Kilohertz FieldShift™ (kHz-FS™) technology, users can instantly shift from large-FOV mesoscopic imaging to localized kilohertz-rate scanning — ideal for calcium or voltage imaging, neural dynamics, and high-speed optogenetics.

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MESOscope

Adaptable design (Ex vivo experiment)

Unmatched Capabilities

Discover what makes Mesoscope stand out with its revolutionary kilohertz-speed cellular imaging and submicron digital precision.

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Millimeter-scale FOV with Submicron Digital Resolution

Up to 1 mm FOV with high-NA (>0.9) 20X objective lens — submicron digital resolution with fulfilled Nyquist Shannon criterion — No optical zooming needed.

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Kilohertz Imaging Capability

Up-to 1500 fps laser-scanning (4 channels, 16 Y-lines) — Ideal for calcium imaging, voltage imaging, neural dynamics, and high-speed optogenetics.

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Ultrahigh Digital Resolution

Up-to 8192 × 8192 pixels per frame to reveal cellular and subcellular detail at pixel size <0.2 µm — ideal for stitching-free large-area imaging.

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One-Click Kilohertz FieldShift™ (kHz-FS™)

From a mesoscopic overview to high-speed cellular dynamics in a single click — instantly boost the frame rate to kilohertz speed and visualize rapid activity within the selected region — seamlessly overlaid on the full field.

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Rapid Artifact-Compensated 2D Large-Field Mosaic-Stitching (rac2D-LMS™)

Gigapixel scanning of centimeter-scale area up to 20 mm × 20 mm (up to 57000 × 57000 px) in real time with automatic, GPU-accelerated stitching algorithms — No post-processing needed.

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True Real-Time Imaging with mesoXScan™

From scanner to screen within milliseconds — GPU-accelerated mesoXScan™ software suite enables near real-time distortion correction and calibration to deliver live visualization.

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Jitter-Suppressed Triggering

Built-in phase-locked loop (PLL) for line-synchronized triggering — ensures artifact-free imaging.

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Integrated Laser Safety

Native control of laser-safety shutter — real-time sensor feedback ensures secure operation.

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Firmware Flexibility

Configurable firmware — supports external frame/trigger I/O, analog and I²C sensors/peripherals, stepper-motor and LED drivers, adapting seamlessly to your experimental needs.

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Adaptable Design

Compatible with both in vivo and ex vivo applications, offering unparalleled flexibility with a detachable external 3D stage.

Technical Specifications

Detailed specifications for our MESOscope models.

Model	MESOscope Pro
Excitation wavelength	900–1100 nm
Operating channels	4
Fast axis frequency	4 kHz or 8 kHz or 12 kHz
Field of View (FOV)	1 mm × 1 mm (20x, 4 kHz) 0.4 mm × 0.4 mm (40x, 8 kHz or 12 kHz)
Resolution	Submicron digital resolution *Fulfills the Nyquist–Shannon Sampling Theorem
Max. image area	10 mm × 10 mm (real-time mosaic-stitching)
Max. image size	8192 × 8192 (4 kHz) *Subject to laser repetition rate
Numerical aperture	≥0.8
Bidirectional scan	Yes
Ultrafast sampling	Yes up to 500 M/s (2 channels) up to 125 M/s (4 channels)
Bright field imaging	Yes (CMOS)
3D stage	External (25 mm XY, 20 mm Z) Internal (10 mm Z)
Computer	Included (4 TB SSD, 64 GB RAM, 24 GB Graphics)
Monitor	Included 4K (3840 × 2160)
External controller	None
Software	Basic imaging (up to 4 channels) Denoised Contrast Enhancement (DCE) Real-time mosaic-stitching
Operating temperature	20–35 °C
Power input	125/250V AC 50/60 Hz

Model	MESOscope
Excitation wavelength	900–1100 nm
Operating channels	2
Fast axis frequency	4 kHz
Field of View (FOV)	0.7 mm × 0.7 mm (20x)
Resolution	Submicron digital resolution *Fulfills the Nyquist–Shannon Sampling Theorem
Max. image size	4096 × 4096 *Subject to laser repetition rate
Numerical aperture	≥ 0.8
Bidirectional scan	Yes
Ultrafast sampling	Yes up to 80 M/s
3D stage	External (25 mm XY, 20 mm Z)
Computer	Included (2 TB SSD, 32 GB RAM, 16 GB Graphics)
Monitor	Included 4K (3840 × 2160)
External controller	None
Software	Basic imaging (up to 2 channel)
Operating temperature	20–35 °C
Power input	125/250V AC 50/60 Hz

MESOscope- MS100

Unmatched Capabilities