Background Image of Tumor

MESOscope Ex Vivo
MESOscope In Vivo
MESOscope Front View
MESOscope Right Side
MESOscope Back Side
MESOscope Left Side

MESOscope Innovation

"A Nonlinear Optical Microscope providing millimeter-scale Field-of-View with submicron digital resolution"

MESOscope is a patented, industry-leading nonlinear optical microscope with up to 4 parallel channels, delivering submicron digital resolution across a millimeter-scale field of view—meeting the Nyquist-Shannon criterion. Its detachable external stage supports both ex vivo and in vivo imaging. GPU-accelerated mosaic stitching enables post-processing-free, sub-minute gigapixel scans at >500 Mbps. A proprietary high-speed mode supports multichannel kilohertz frame-rate imaging for functional studies. Compact and versatile, MESOscope fits a wide range of experimental needs.

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PATHOscope System

Unmatched Capabilities

Discover what makes MESOscope stand out with its cutting-edge features.

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Gigapixel Imaging

Capture centimeter-scale fields with submicron digital resolution—no post-processing required, ensuring immediate insights.

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No Optical Zooming

Full FOV maintained at high resolution without optical zoom or FOV shrinking—preserving true spatial detail across the entire sample.

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KHz Frame Rate

Achieve up to 1000 fps at 4096×15 resolution using an 8 kHz scanner—ideal for high-speed voltage imaging and dynamic studies.

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Nyquist Fulfilled Imaging

Digital resolution precisely equals optical resolution across the full FOV—eliminating aliasing or interpolation artifacts.

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Real-Time Mosaic Stitching

Scan up to 20×20 mm areas in real time with automatic, GPU-accelerated stitching and zero post-processing delay.

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Adaptable Design

Compatible with both in vivo and ex vivo applications, offering unparalleled flexibility with a flexible external 3D stage.

Streamline your research with MESOscope
Brain (Tumor)
High resolution neuronal structures
Brain (Normal)
Mouse brain medulla (tdTomato)
Brain (Normal)
Intact trigeminal tract (tdTomato)
Full View
MESOview PATHOscope In Vivo and Ex Vivo models

Key Advantages

  • High-speed Resonant-Galvo scanning
  • 1 mm FOV with submicron resolution
  • Adaptable for in vivo and ex vivo imaging
  • Supports 4-channel multi-color imaging
  • High-speed imaging up to 800 fps
  • Ultrafast sampling up to 500 M/s
  • Real-time mosaic stitching for gigapixel imaging
  • GPU-accelerated acquisition software

Technical Specifications

Detailed specifications for our MESOscope models to help you choose the best fit.

Model MESOscope Pro
Excitation wavelength 900–1100 nm
Operating channels 4
Fast axis frequency 4 kHz or 8 kHz or 12 kHz
Field of View (FOV) 1 mm × 1 mm (20x, 4 kHz)
0.4 mm × 0.4 mm (40x, 8 kHz or 12 kHz)
Resolution Submicron digital resolution
*Fulfills the Nyquist–Shannon Sampling Theorem
Max. image area 10 mm × 10 mm
(real-time mosaic-stitching)
Max. image size 8192 × 8192 (4 kHz)
*Subject to laser repetition rate
Numerical aperture ≥0.8
Bidirectional scan Yes
Ultrafast sampling Yes
up to 500 M/s (2 channels)
up to 125 M/s (4 channels)
Bright field imaging Yes (CMOS)
3D stage External (25 mm XY, 20 mm Z)
Internal (10 mm Z)
Computer Included
(4 TB SSD, 64 GB RAM, 24 GB Graphics)
Monitor Included 4K (3840 × 2160)
External controller None
Software Basic imaging (up to 4 channels)
Denoised Contrast Enhancement (DCE)
Real-time mosaic-stitching
Operating temperature 20–35 °C
Power input 125/250V AC
50/60 Hz

Streamline your research with MESOscope

Streamline your research with MESOscope

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MESOscope
Neuronal Connectomics
Molecular Visualization
Complex Interactions
Cellular Imaging
Neuronal Connectomics
Molecular Visualization
Complex Interactions
Cellular Imaging